Homofermentive lactate production cannot sustain anaerobic growth of engineered saccharomyces cerevisiae: Possible consequence of energy-dependent lactate export

Article Abstract:

Saccharomyces cerevisiae is engineered to homofermentative lactate-producing yeast through deletion of the three genes encoding pyruvate decarboxylase-negative S.cerevisiae strains, the engineered strain required small amounts of acetate for the synthesis of cytosolic acetyl-coenzyme. The conclusion states that the absence of net ATP production is probably due to a metabolic energy requirement for lactate export.

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Physiological characterization of the ARO10-dependent, broad-substrate-specificity 2-oxo acid decarboxylase activity of Saccharomyces cerevisiae

Article Abstract:

A study was conducted to analyze the substrate specificity of the ARO10-dependant decarboxylase activity in Saccharomyces cerevisiae, and its impact on the production of fusel alcohols and acids. The studies conducted indicate the involvement of post-transcriptional regulation and a second protein in the ARO10-dependent, broad-substrate-specificity decarboxylse activity.

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Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae

Article Abstract:

Research has been conducted on genes encoding Saccharomyces cerevisiae phenylpyruvate decarboxylase. The authors have investigated the hypothesis that S. cerevisiae genes for thiamine diphosphate-dependent decarboxylases encode physiologically relevant phenylpyruvate decarboxylaseactivity in wild-type S. cerevisiae, and they report the results.

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