Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

Article Abstract:

Study is conducted to show that histone deacetylase 7 (HDAC7), expressed during early embryogenesis, maintains vascular integrity by repressing matrix metalloproteinase10, which is a secreted endoproteinase. Findings reveal an unexpected and specific role of HDAC7 in the maintenance of vascular integrity and have important implications for understanding the processes of angiogenesis and vascular remodeling during cardiovascular development and disease.

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Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

Article Abstract:

Histone deacetylase (HDAC4) regulates chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy. The findings suggest a general role for class II HDACs as negative regulators of cellular hypertrophy during development and disease.

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Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

Article Abstract:

Myocardin is a transcriptional cofactor of serum response factor and belongs to the SAP domain family of nuclear proteins. Myocardin is expressed in embryonic cardiac and smooth muscle cells and in late stages it becomes restricted to the myocardium. Further, it activates cardiac muscle promoters by associating with serum response factor.

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