Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation

Article Abstract:

Linker histone H1 plays an important role in chromatin folding in vitro and in order to study the role of H1 in vivo, mouse embryonic stem cells null for three H1 genes were derived and were found to have 50% of the normal level of H1. Results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns.

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REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis

Article Abstract:

The transcriptional repressor REST (RE1 silencing transcription factor) regulates the transitions from pluripotent to neural stem/progenitor cell and from progenitor to mature neuron. In the transition to progenitor cell, REST is degraded to levels just sufficient to maintain neuronal gene chromatin in an inactive state that is nonetheless poised for expression.

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Proline isomerization of histone H3 regulates lysine methylation and gene expression

Article Abstract:

The proline isomerization of histone tails is identified as a novel chromatin modification that controls transcription. An analysis of the FK506 binding protein Fpr4 demonstrates that histones H3 and H4 tails in vitro can be tightly bound by it.

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