Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination

Article Abstract:

A recombination-promoting complex (RPC) containing Swi2 and Swi5 proteins exhibits a cell type-specific localization pattern at the silent mating-type region and this differential localization modulates donor preference during mating-type switching. Analyses implicate heterochromatin in long-range regulatory interaction and suggest that heterochromatin imposes a structural organization at the mating-type region that is important for the donor-choice mechanism.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

The TAFs in the HAT

Article Abstract:

The transcriptional roles of ten associated factors (TAFs) and their corresponding biochemical influence within the context of the multiprotein complex TFIID were reviewed. TAFs play a major role in core promoter functions as well as enhancing the level of transcription derived from TATA containing promoters. In addition, previous studies have uncovered TAFs' function in the SAGA complex.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction

Article Abstract:

Hog1 phosphorylation stimulates Nha1 activity and is crucial for the rapid reassociation of proteins with their their target sites in chromatin. This initial response to hyperosmolarity precedes and temporally regulates the activation of stress-response genes that depends on Hog1 phosphorylation of transcription factors in the nucleus.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: