Article Abstract:
Construction of genetic screens has revealed that a member of the tumor necrosis factor/nerve growth factor receptor family mediates herpes simplex virus-1 (HSV-1) penetration into cells. Designated the herpesvirus entry mediator (HVEM), this receptor was shown to enhance the entry of HSV-1 and HSV-2 strains into infected CHO-K1 and ST cell lines by interacting with one or more of the virion envelope glycoproteins. Infection was inhibited by anti-HVEM antibodies or HVEM:Fc as a result of direct interaction with virion surface proteins.
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Article Abstract:
Axons in the nervous systems of vertebrates are sheathed with the multilamellar membrane myelin, which is enriched with the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. In the case of mice lacking the required enzyme for GalC synthesis, myelin containing glucocerebroside is formed. However, the myelin formed, while of normal appearance, exhibit reduced insulative capacity and severe generalized tremoring and mild ataxia. These indicate the importance of GalC and sulfatide in myelination.
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Article Abstract:
A sensitive DNA PCR technique helps determine the exact number of Epstein-Barr virus (EBV)-infected cells in vivo and identify the type of cells infected and the form of infection. Peripheral blood EBV infection occurs primarily in the latently-infected CD23(-)CD80(-) B cells. The latent EBV yields the infectious lethal virus immediately on reactivation. Infected cell frequency is low, but stable over a period of time, representing a new form of latency in normal B cells.
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