Article Abstract:
A novel role for Hedgehog signaling in speeding up the cell cycle in the developing retina by reducing the length of G1 and G2 phases is described. These fast cycling cells tend to exit the cell cycle early and retinal progenitors with blocked Hedgehog signaling cycle more slowly, with longer G1 ad G2 phases and remain in the cell cycle longer which indicates that Hedgehog might play a role in regulating the conversion from slow cycling 'stem' cell to a faster cycling 'transit amplifying' progenitor cell.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Genetic analysis in Drosophila melanogaster, which has only one myb gene, has shown Drosophila myb is necessary for maintenance of diploidy and the G2/M transition. Dm myb is necessary for prevention of endoreduplication in wing cells and mitosis. It seems that myb is effective at about the time of the G2/M transition. There is a cellular explanation for the requirement of the phenotypes of the mutants for myb in various cellular lineages in the development of Drosophila.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A prevalent model is proposed for thiamin pyrophosphate (TPP) riboswitch-controlled gene expression in all flowering plants. It has shown that the TPP binding to THIAMINE C SYNTHASE (THIC) pre-mRNA has engendered alternative splicing leading to the generation of an unstable transcript and thus lowering TPP biosynthesis.
User Contributions:
Comment about this article or add new information about this topic: