Hedgehog-regulated localization of Vax2 controls eye development

Article Abstract:

Study shows that Vax2, a homeodomain protein that ventralizes the vertebrate eye field by repressing transcription of the Pax6 gene shuttles between the nucleus and cytoplasm as a function of time in eye development, and that this dynamic shuttling is an essential feature of retinal differentiation. It is indicated that regulated changes in Vax2 localization modify the developmental competence of the optic neuroepithelium over time and thereby provide a mechanism for the sequential staging of eye development.

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Local regulation of fat metabolism in peripheral nerves

Article Abstract:

Research demonstrates a large cluster of genes associated with the metabolism of storage lipids. These genes are expressed by adipocytes and mutation in some of these genes lead to peripheral neuropathy.

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The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain

Article Abstract:

Results demonstrate that the homeodomain protein Vax1 in mutants exhibit significant defects in the optic nerve axon guidance and ventral anterior midline of the developing mammalian forebrain.

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