Hedgehog/Ras interactions regulate early stages of pancreatic cancer

Article Abstract:

The generation of a novel mouse model of pancreatic cancer based on epithelium-specific activation of the Hedgehog signaling pathway is described. The results have indicated the cooperation of Hedgehog and Ras signaling during the earliest stages of pancreatic ductal adenocarcinoma (PDA) formation and they have also marked Hedgehog pathway components as relevant therapeutic targets for both early and advanced stages of pancreatic ductal neoplasia.

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Sustained hedgehog signaling is required for basal cell carcinoma proliferation and survival: Conditional skin tumor genesis recapitulates the hair growth cycle

Article Abstract:

The temporally and spatially constrained Hedgehog (Hh) signaling regulates the cyclic growth of hair follicle epithelium whereas the constitutive Hh signaling drives the development of basal cell carcinomas (BCCs). The study carried out on the Hh signaling reveals that continued Hh signaling is required for proliferation and survival of established BCCs.

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PR72, a novel regulator of Wnt signaling required for Naked cuticle function

Article Abstract:

PR72, which is a protein phosphatase type 2A regulatory subunit of unknown function, is studied. The results indicate that PR72 interacts physically and functionally with Naked cuticle and acts as a negative regulator of Wnt signaling cascade, thus proving PR72 to be a novel regulator of the Wnt signaling pathway.

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