Haplotype analysis for Icelandic families defines a minimal interval for the macular corneal dystrophy type I gene

Article Abstract:

Location of the gene for macular corneal dystrophy (MCD) type 1 has been narrowed to a region of less than 1 cM between markers D16S3115 and D16S3083 through a haplotype analysis of 10 Icelandic families. Evidence also suggests that the different immunophenotypes of MCD may be allelic. MCD type I in Iceland may have been caused by multiple mutations or else a very old mutation with multiple recombinants.

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Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration

Article Abstract:

A study to identify statistically the most likely age-related macular degeneration (AMD) -susceptibility allele by using the Genotype-IBD sharing test and conditional haplotype analysis is presented. Genetic susceptibility coupled with a modifiable lifestyle factor such as cigarette smoking confers a significantly higher risk of AMD than either factor alone.

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Peakwide mapping on Chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease

Article Abstract:

A susceptibility locus for coronary artery disease (CAD) is mapped to chromosome 3q13-21 in a linkage study of early-onset CAD to examine the association between genotype and aortic atherosclerosis. The peakwide survey found evidence of associations from the kalirin (KALRN) gene, especially in patients with early-onset CAD.

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