D114, a novel Notch ligand expressed in arterial endothelium

Article Abstract:

Research has been conducted on D114 gene of the Notch ligands. The results of the cloning and characterization of this gene are presented.

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Notch signaling is essential for vascular morphogenesis in mice

Article Abstract:

Research has been conducted on the role of the Notch4 gene in the intercellular signaling mechanism. The generation of the Notch4-deficient mice by gene targeting is described.

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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Article Abstract:

The mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit happloinsufficient lethality because of defects in vascular remodeling is reported. Notch pathway mutant embryos exhibit defects in arterial specification of nascent blood vessels and develop arteriovenous malformations.

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