HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans

Article Abstract:

The mechanisms responsible for homolog alignment, synapsis and recombination are closely coordinated during meiosis in order to culminate in the formation of crossovers capable of directing accurate chromosome segregation. The study has identified that HTP-1 is a key regulator of synapsis that is required to prevent premature assembly of SC components relative to homolog alignment during meiosis and also HIM-3 family of proteins plays a key role in coordinating of early meiotic events.

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Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis

Article Abstract:

The activation and importance of Netrin receptor UNC5B during embryonic development and postnatal and pathological angiogenesis are studied. The analysis reveals that UNC5B can be widely used as a potential anti-angiogenic target, as it inhibits sprouting angiogenesis.

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Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation

Article Abstract:

The mouse gene is disrupted encoding transverse filaments (TF) protein Sycp1 to analyze the role TFs in meiotic chromosome behavior and recombination. It is proposed that SYCP1 has a coordinating role, and ensures formation of crossovers.

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