Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation

Article Abstract:

A study was conducted to investigate the regulation of Discs large (DLG) localization at synapses. The synaptic DLG localization was found to be mediated by CaMKII-dependent phosphorylation. The constitutive activation of CaMKII or a point mutation that mimicked CaMKII phosphorylation of DLG both led to a significant increase in extrasynaptic DLG. These results strongly suggest that changes in synaptic structure and composition induced by changing CaMKII activity are due to changes in DLG distribution.

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Glial control of synaptogenesis

Article Abstract:

Glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation. The mechanisms inducing the formation between neurons that occur through synapse are studied.

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Glial control of synaptogenesis

Article Abstract:

Glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation. The mechanisms inducing the formation between neurons that occur through synapse are studied.

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