Genome-wide mRNA surveillance is coupled to mRNA export

Article Abstract:

The discovery of four new factors required for mRNA export through a screen of all annotated nonessential Saccharomyces cerevisiae genes is reported. Results demonstrate coupling of mRNA surveillance to mRNA export and suggest specificity of the RNA surveillance machinery for different transcript populations.

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The role of protein arginine methylation in the formation of silent chromatin

Article Abstract:

The role played by the protein arginine methyltransferase Hmt1 in the preservation and establishment of silent chromatin domains is examined. The results have shown a novel function for arginine methylation in the maintenance of genome stability and the establishment of silent chromatin.

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Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors

Article Abstract:

Hmt1 is recruited during the beginning of the transcriptional elongation process. The research data suggest a model whereby Hmt1 affects transcriptional elongation and influences recruitment of RNA-processing factors.

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