Genome-wide identification of replication origins in yeast by comparative genomics

Article Abstract:

Study is conducted to determine genome-wide location of replication origins at a resolution sufficient to identify the sequence elements bound by replication proteins and to demonstrate that most replication origin sequences are phylogenetically conserved among closely related Saccharomyces species. The results show that phylogenetic conservation can be used to identify the origin sequences responsible for replicating enkaryotic genome.

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A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast

Article Abstract:

A new component of the Cdc42- and MAPK-dependent signaling pathway that reduces filamentous growth (FG) in yeast is analyzed using genomic approaches. The Ms2b, a FG-specific factor that promotes activation of the MAPK for the FG pathway is found to be a signaling mucin that interacts with the general components, such as Cdc42 and Sho1, to promote their function in the FG pathway.

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Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically mutant

Article Abstract:

Isw2 ATP-dependent chromatin-remodeling activity is targeted to early meiotic and MATa-specific gene promoters in Saccharomyces cerevisiae. However, no evidence was found for Isw2 function at sites preferentially enriched by wild-type Isw2p, leading to the proposal that wild type Isw2p cross-linking revealed a scanning mode of the complex as it surveyed the genome for its targets.

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