Genome scanning by composite likelihood

Article Abstract:

Genomewide databases for meta-analysis of association between DNA markers and phenotypes of medical and/or social concern are launched, for which accurate estimates for both genomic location and its standard error are provided by composite likelihood. The Malecot model for association mapping is applied with an illustrative example and the inferences are presented, while also proposing an extension to meta-analysis.

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Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables

Article Abstract:

Multifactor dimensionality reduction (MDR) phenomic method is used to determine the genetic effects within triad families by integrating phenotypic covariates (PCs) into MDR. The method is more powerful to capture genetic heterogeneity.

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Canine behavioral genetics: pointing out the phenotypes and herding up the genes

Article Abstract:

An understanding of a representative subset of canine behaviors as well as approaches for phenotyping, genome-wide scans and data analysis are described. The applicability of studies of canine behavior to human genetics is discussed.

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