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Genetics of O-antigen biosynthesis in Pseudomonas aeruginosa

Article Abstract:

A study has been conducted to investigate the role of lipopolysaccharides (LPS) as a determinant of virulence in vaccination preparations and to analyze its chemistry and biosynthesis of the O-antigenic region due to its immunogenicity, serotype specificity and serum resistance properties. Findings have indicated that the A-band and B-band O antigens produced by Pseudomonas aeruginosa are synthesized by independent mechanisms. It has also been found that the only protein common to both systems is glycosyltransferase WbpL.

Endotoxins, Pseudomonas aeruginosa, Biosynthesis, Bacterial antigens, O antigens

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Molecular regulation of beta-lactam biosynthesis in filamentous fungi

Article Abstract:

Studies on the regulation of biosynthesis of beta-lactam antibiotics were conducted to help elucidate the physiological and ecological functions of beta-lactams for the producing fungi. Biosynthetic pathways leading to penicillin and cephalosporin, two most common beta-lactam antibiotics, begin from the same three amino acid precursors and possess the first two enzymatic reactions in common. Findings suggest that fungal beta-lactam biosynthesis is regulated by a complex regulatory network.

Drug therapy, Communicable diseases, Molds (Fungi), Beta lactam antibiotics

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