Degradation of Drosophila PIM regulates sister chromatid separation during mitosis

Article Abstract:

Degradation of Drosophila Pimples (PIM) protein has been found to regulate sister chromatid separation in mitosis. The nonconserved Drosophila genes, pimples and three rows, both necessary specifically for sister chromatid separation in mitosis, have been identified. PIM shares extensive functional similarity with securin proteins and with Cut2 from fission yeast an is found in a comlex with Three rows protein.

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Drosophila Separase is required for sister chromatid separation and binds to PIM and THR

Article Abstract:

Drosophila Separase has been found to be necessary for sister chromatid separation and it binds to THR and PIM, which associate in vivo. The Drosophila SSE sequence is very diverged. Some features conserved in homologs from trypanosomatids to vertebrates are not seen in it.

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Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog

Article Abstract:

Study is conducted in which a genetic loci is screened that modify the aberrant phenotypes caused by over expression of regulatory separase complex subunits Pimples/securin and Three rows in Drosophila. An interacting gene is found to encode a constitutive centromere protein.

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