Article Abstract:
Results of a large interview study show no significant increase in genetic disease among offspring of cancer survivors. For 2198 offspring of survivors, 3.4% had genetic disease, compared with 3.1% among 4544 offspring of controls. Cytogenetic syndromes, single-gene defects, and simple malformations also were not significantly different. The study involved adult survivors of childhood cancer who had been treated before 1976. The study had 80% power to identify an increase as low as 40%, and no such effect was found.
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Article Abstract:
Children of cancer survivors do not appear to have increased risk of congenital anomalies, according to results of a study by J. Byrne et al. The study is notable because of the large size of the study cohort. The researchers also classified the observed congenital anomalies according to whether germ-cell mutation was a likely cause. The study involved 2,198 children with a parent who had been treated for a brain tumor or malignancy during childhood or adolescence.
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Article Abstract:
Mutations in the Wilms tumor 1 (WT1) gene were not found in 20 patients with isolated diffuse mesangial sclerosis (DMS) nor in seven patients with isolated focal segmental glomerulosclerosis (FSGS). WT1 mutations may be regarded as evidene of Denys-Drash syndrome or Frasier syndrome when found in patients with DMS or FSGS.
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