Article Abstract:
Transgenic mice with reduced protein kinase A (PKA) activity due to the expression of R(AB) in the forebrain region were analyzed to determine the role of PKA in the late phase of long-term potentiation (L-LTP). Analysis of PKA activity during L-LTP and hippocampus-based long-term memory in R(AB)transgenic mice indicated the role of PKA signaling pathway in the expression of the early component of L-LTP in the hippocampal area CA1. Furthermore, PKA-mediated expression of L-LTP was essential for explicit forms of long-term memory storage.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
The absence of protein kinase A (PKA) suppresses the development of long-term potentiation (LTP) in the hippocampal mossy fiber pathway, but this has no effect on spatial and contextual learning. Mutant mice without the C-beta-1 or RI-beta isoforms of PKA have the same learning abilities of space and context as wild-type mice. This is probably due to the transfer of information to the CA1 region of the brain from the entorhinal cortex in the absence of LTP.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Stathmin, an inhibitor of microtubule formation was identified as highly expressed in the later nucleus (LA) of the amygdala and in the thalamic and cortical structures that send information to the LA about the conditioned and unconditioned stimuli. The whole-cell recordings from amygdala slices that are isolated from stathmin knockout mice show deficits in spike-timing-dependent long-term potentiation.
User Contributions:
Comment about this article or add new information about this topic: