Genetic association of apolipoprotein E with age-related macular degeneration
Article Abstract:
It appears that the apolipoprotein E (apoE) gene (APOE) is a susceptibility gene for age-related macular degeneration (AMD). It has been found that apoE staining was consistently present in the disease-associated deposits in AMD-maculae. In 15 AMD and 10 control maculae apoE immunoreactivity has been studied. Researchers have undertaken a study to determine whether or not apoE is directly involved in the pathogenesis of AMD.
author: Hofman, Albert, Grobbee, Diederick E., Cruts, Marc, Duijn, Cornelia M. van, Klaver, Caroline C.W., Jong, Paulus T.V.M. de, Kliffen, Mike, Broeckhoven, Christine van
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
United States, Netherlands, Belgium, Apolipoproteins, Chromosome mapping, Genetic disorders, Retinal degeneration, Geriatric ophthalmology
A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions
Article Abstract:
The scientific advantages of using predictive genetic profiling for providing personalized nutrition and health recommendations to the consumers are presented. The commercialization of genomic profiles is found to have no scientific significance for assessing health-risks or giving personalize health interventions to the patients.
author: van Duijn, Cornelia M., Gwinn, Marta, Khoury, Muin J., Oostra, Ben A., Janssens, A. Cecile J.W., Bradley, Linda A.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Type 2 diabetes, Health risk assessment, Meta-analysis
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
Article Abstract:
Three genome-wide analyses are conducted to establish the HERC2 gene as a new and potential determinant of the human iris color gene variation.
author: Hofman, Albert, van Duijn, Cornelia M., Uitterlinden, Andre G., Vingerling, Johannes R., Klaver, Caroline C.W., Despriet, Dominiek D.G., Oostra, Ben A., Fan Liu, Aulchenko, Yurii S., Kayser, Manfred, Heath, Simon, Janssens, A. Cecile J.W., Rivadeneira, Fernando, Lao, Oscar, van Duijn, Kate, Vermeulen, Mark, Arp, Pascal, Jhamai, Mila M., van Ijcken, Wilfred F.J., den Dunnen, Johan T., Zelenika, Diana, de Jong, Paulus T.V.M.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
Observations, Color of eyes, Eye color, Genetic variation, Eye colour
subjects list: Research, Usage, Genetic aspects, Genomics
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