Genetic and molecular characterization of P element-induced mutations reveals that the Drosophila ovarian tumor gene has maternal activity and a variable phenotype

Article Abstract:

Alterations in the Drosophila ovarian tumor gene stops oogenesis at various stages. Characterization of various mutations ranging from the absence to a decrease of otu transcripts was undertaken to study otu functions. Heteroallelic combinations produce a range of phenotypes suggestive of the dosage-dependence of the various phenotypes. The development of female germlinewas also shown to be dependent on maternal otu activity. Further, the otu zygotic null phenotype was demonstrated to be variable.

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Structure and expression of hybrid dysgenesis-induced alleles of the ovariantumor (otu) gene in Drosophila melanogaster

Article Abstract:

Insertion or deletion mutation in the Pelement of the Drosophila melanogaster ovarian tumor (otu) gene were analyzed to correlate otu mutant phenotypes with otu expression levels. Results show that the different mutations induced produced varying phenotypes ranging from quiescent mutants exhibiting reduced cell proliferation to oncogenic mutants exhibiting uncontrolled cell proliferation without differentiation. This indicate that the varying levels of otu function produce a range of phenotypes.

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The ovarian tumor protein isoforms of Drosophila melanogaster exhibit differences in function, expression, and localization

Article Abstract:

Immunolocalization experiments and Western analysis confirm that the accumulation of the Drosophila melanogaster ovarian tumor (otu) gene isoforms is developmentally regulated. Predifferentiated stages have high levels of otu-104, while differentiated egg chambers have high levels of otu-98. The 104-kDa isoform rather than the 98-kDa isoform is essential for normal proliferation of female germline cells and for oocyte differentiation. Completion of oocyte maturation requires the 98-kDa isoform.

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