Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

Article Abstract:

The target of Drosophila rapamycin, dTOR, has been identified and characterized genetically and biochemically. It is a candidate effector for nutritional sensing. Genetic and biochemical analyses show that dTOR has an effect on insulin signaling pathways by affecting growth by modulating activity of dS6K autonomously. Partial loss of dTOR activity lowers growth of the endoreplicating tissues preferentially. It appears that dTOR is on a parallel amino acid sensing pathway

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

Article Abstract:

Cellular growth and its regulation by the Drosophila target of rapamycin are discussed. Mutations in the Drosophila TOR homolog, dTOR, were generated, and it was seen that dTOR mutant phenotypes recapitulate aspects of both P13K-dependent signaling and nutritional sensing. That would be consistent with dTOR's acting at the junction of the pathways examined.

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A nutrient sensor mechanism controls Drosophila growth

Article Abstract:

Research shows that organismal growth in Drosophila is initiated by the fat body possessing endocrine and storage functions of the vertebrate liver. Data indicate that the fat body functions as a nutrient sensor and contains slimfast gene whose downregulation leads to a global growth defect similar to that exhibited by Drosophila raised under poor nutritional conditions.

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