Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway

Article Abstract:

Isolation of Arabidopsis thaliana mutants that do not exhibit a triple response to exogeneous ethylene form five new complementation groups. While the ein4, ein5, ein6 and ein7 groups are not sensitive to ethylene, the fifth eir1 group is formed by a new group of mutants with agravitropic and ethylene-insensitive roots. The ETR1, CTR1, EIN2, EIN3, EIN4, EIN5, EIN6, AUX1, EIR1, and HLS1 constitute the ethylene-response pathway. The root-specific ethylene response, which does not require the activity of EIN3 and EIN5 genes, are formed by the EIR1 and AUX1 loci.

author: Ecker, Joseph R., Kieber, Joseph J., Rothenberg, Madge, Roman, Gregg, Lubarsky, Barry
Analysis, Arabidopsis thaliana

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Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins

Article Abstract:

Nuclear protein ETHYLENE-INSENSITIVE3 (EIN3) and related proteins were analyzed to determine their role in the activation of the ethylene gas response pathway in Arabidopsis. The study utilized various strains, growth conditions and genetic analysis to identify and describe the EIN3-like genes whose predicted translation products have characteristics found in regulatory proteins. Results reveal that mutations in the EIN3 gene in Arabidopsis deter a plant's response to ethylene and that loss of ethylene-mediated effects could lead to an enhanced senescence.

author: Ecker, Joseph R., Solano, Roberto, Rothenberg, Madge, Roman, Gregg, Chao, Qimin, Terzaghi, William
Research, Proteins

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CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the Raf family of protein kinases

Article Abstract:

A new Arabidopsis gene was identified using the triple response of dark grown seedlings to isolate constitutive triple response (ctr) mutants. The gene, designated CTR1, acts downstream of EIN1 but upstream of the EIN3 gene product. Sequence analysis showed that the protein encoded by CTR1 is highly similar to the serine/threonine protein kinases. It is proposed that CTR1 acts as a negative regulator of a multistep signal transduction pathway via phosphorylation of protein(s) in a cascade.

author: Ecker, Joseph R., Kieber, Joseph J., Rothenberg, Madge, Roman, Gregg, Feldmann, Kenneth A.
Identification and classification, Protein kinases, Phosphorylation

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subjects list: Physiological aspects, Genetic aspects, Cellular signal transduction, Ethylene, Arabidopsis
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