Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

Article Abstract:

Research into signal transduction has led to the conclusion that while the activation of specific receptors leads to highly specific biological responses, the activation process itself requires only the presence of ubiquitous signaling intermediates. A model of signal transduction is presented wherein calcineurin, cytoplasmic NF-ATs and Ca2+ play key roles in the signaling pathway. The model suggests that pharmacological specificity on generic calcium signals can be used to identify ways to channel signals into specific responses.

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A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

Article Abstract:

Hearth valve morphogenesis in mice is studied and it is found that its initiation requires calcineurin/NFAT to repress VEGF expression in the myocardium underlying the site of prospective valve formation. This repression of VEGF is essential for the formation of mesenchymal cells through endocardial cell transformation.

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Signals transduced by calcium(sup)2+/calcineurin and NFATc3/c4 pattern the developing vasculature

Article Abstract:

Results demonstrate that signals between growing vessels and supporting tissues mediated by calcium, calcineurin, and NFATc3/c4 genes promote the anatomical pattern of the developing vasculature.

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