Article Abstract:
Erythroid lineage committment requires neither erythropoietin (EPO), the main growth factor controlling the production of circulating erythrocytes, nor EPO receptor (EPOR). However, definitive erythropoiesis requires EPO and EPOR. Proliferation and differentiation of burst-forming unit-erythroid (BFU-E) to colony-forming unit-erythroid (CFU-E) also do not require EPO and EPOR, but they are required for proliferation and survival of CFU-E progenitors and their terminal differentiation.
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Article Abstract:
Stat5 is a vital component of erythropoietin receptor's antipoptotic signaling. Analysis of severely anemic Stat5a-/-5b-/- mouse embryos reveals that the absence of Stat5 results in a rise in the apoptosis of Stat5a-/-5b-/- progenitors. In the case of wild-type fetal liver progenitors, increased apoptosis and reduced Epo-dependent cell growth occur with the inhibition of Stat5 function by either of the two unique dominant-negative Stat5 proteins.
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Article Abstract:
The detection of 2-fold differences in the X chromosome and the inactivation of a single X chromosome in female cells have been achieved through the discovery of the mouse Xist gene and the human XIST gene. It was revealed that X inactivation required steps such as choice, initiation and spread. Despite these discoveries, the processes by which cells propagate and initiate X inactivation are still unknown.
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