Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

Article Abstract:

Research has been conducted on the CREB- binding protein (CBP). Results indicate that CBP has tumor-suppressor activity.

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Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300

Article Abstract:

Laboratory mice that do not have the functional p300 gene were studied to determine the impact of the genetic defect on embryonic development, specifically neurulation, cell proliferation and heart development. Results revealed proliferation defects in the said embryos. Embryonic lethality was also observed among p300 heterozygotes. These findings indicated that mammalian cell proliferation and development requires a coactivator endowed with histone acetyltransferase activity.

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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

Article Abstract:

The hypoxia-inducible factor, HIF-1, must recruit p300/CBP in order for the transcriptional response to hypoxia to take place. Interaction between HIF-1alpha and the p300/CBP CH1 region must be present. A new p300-CH1 interacting protein has been identified and cloned and it is called p35srj. In hypoxic cells, p35srj may be the regulator of HIF-1 transactivation. It may control access of HIF-1alpha to p300/CBP. It also may keep a significant portion of p300/CBP, compartmentalizing cellular p300/CBP.

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