GDNF/Ret signaling and the development of the kidney

Article Abstract:

The signaling by glial cell-line-derived neurotrophic factor (GDNF) through the Ret receptor is required for normal growth of the ureteric bud during kidney development. Some studies provided new insight into the issue showing that the localized expression of the GDNF by the metanephric mesenchyme, together with several types of negative regulation, is important to elicit and correctly position the initial budding event from the Wolffian duct.

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Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1

Article Abstract:

The effects of glial cell line-derived neurotrophic factor and sprouty1 expressions on mouse ureteric epithelium development are presented.

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VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis

Article Abstract:

The role of vascular endothelial growth factor-A in activating mouse lung morphogenesis is presented.

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