From modulator to mediator: rapid effects of BDNF on ion channels

Article Abstract:

Discussing the findings that establish BDNF as a potent modulator and a direct mediator of postsynaptic ion channel conductance in the central nervous system. BDNF emerges not only as a potent neuromodulator but also as a substance with fast excitatory action on neurons, which acutely controls resting membrane potential, neuronal excitability, synaptic transmission and participates in the induction of synaptic and morphological plasticity.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Renewed debate over postnatal oogenesis in the mammalian ovary

Article Abstract:

The central dogma of female reproductive biology has long held that oogenesis ceases prior to birth n mammals. The debate over whether postnatal oogenesis occurs in the mammalian ovary has resurfaced with the paper by Johnson et al. (2004). The issue can have tremendous effect on aspects related to female fertility and reproductive longevity.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

How consistent are expression chip platforms?

Article Abstract:

DNA arrays are now widely used in academia and industry, and expression profiling is recognised as a major tool for basic research as well as for drug development. It is also likely, in the near future, that DNA arrays will be used in clinical laboratories for diagnostic and prognostic purposes.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: