From amplification to gene in thyroid cancer: a high-resolution mapped bacterial artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization

Article Abstract:

Comparative genome hybridization (CGH) combined with a dense mapped resource of bacterial artificial chromosomes (BACs) and large-scale sequencing has led to definition of a candidate gene previously unmapped and related to thyroid tumorigenesis. CGH data can be translated into higher resolution genomic-clone data that are used to define genes in aneuploid regions by using a newly developed general approach. The CGH method has been used to investigate thyroid-tumor DNAs and two tumor-cell-line DNAs. Amplifications of chromosome band 2p21 were found, and less intense amplification was found elsewhere..

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Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24

Article Abstract:

Further research is needed to determine causal factors for autosomal dominant nocturnal frontal-lobe epilepsy. While evidence suggests a second locus for the disorder at chromosome 15q24 in addition to 20q13.2 with a clinically homogeneous phenotype, a wide range of molecular defects that contribute to the disorder are complicating accurate causal determination.

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A Bayesian measure of the probability of false discovery in genetic epidemiology studies

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The article describe on how Bayesian false-discovery probability (BFDP) can be used for design and multiple-hypothesis' testing context providing the expected numbers of false and missed discoveries.

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