Follow your nose: Axon pathfinding in olfactory map formation

Article Abstract:

New studies related to discrete identities of olfactory sensory neurons, which converted into a spatial map of axonal connections, are reported. It was found that levels of cAMP signals derived from olfactory receptors (ORs) could direct targeting of axons along an axis and that ORs and neural activity regulate expression of adhesion/guidance molecules in mosaic patterns that could sort axons into discrete locations.

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A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting

Article Abstract:

Genes whose expression profiles are correlated with the expressed odorant receptors (ORs) were searched to study how OR-instructed axonal fasciculation is controlled. The findings reveal that a specific set of adhesive/repulsive molecules, whose expression levels are determined by OR molecules, regulate the axonal fasciculation of OSNs during the process of glomerular map formation.

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Control of dendritic branching and tiling by the tricornered-kinase/furry signaling pathway in drosophila sensory neurons

Article Abstract:

Neurons of certain functional groups are known to exhibit tiling of their dendrites. Tricornered (Trc) and kinase and furry (fry) signaling pathway play an important role in patterning dendritic fields.

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