Article Abstract:
Fission yeast cohesin and essential anaphase proteolysis of S phase-phosphorylated Rad21 are discussed. Characterization of four putative cohesin subunits, needed for sister chromatid cohesion, Pac3, Psm1, Psm3, and Rad21 in fission yeast has been carried out for the first time. A simple model for explaining behvaior of fission yeast cohesin has been developed. It also gives an explanation for why a tiny fraction of Rad21 cleaved for normal anaphase is enough.
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Article Abstract:
The anaphase-promoting complex or cyclosome (APC/C), which was discovered four years ago, and cell division are discussed with a summary of available information about (APC/C) roles and regulation. By destroying anaphase inhibitory proteins, the APC/C brings on separation of sister chromatids, and by destroying mitotic cyclins, it sets up the low CDK state necessary for cytokinesis and for reforming the pre-RCs complexes needed for the next round of genome replication.
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Article Abstract:
Fission yeast condensin complex is discussed relative to essential roles of non-structural maintenance of chromosomes (SMC) subunits for Cdc2 phosphorylation and condensation of Cut3/SMC4. Fission yeast has the same five-member condensin complex as the condensin complex in frog extracts, which contains two SMC and three non-SMC subunits, with each of the five members essential for mitotic condensation. Direct phosphorylation of fission yeast condensin may aid in its nuclear accumulation during mitosis.
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