Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway

Article Abstract:

The intracellular adhesion molecule 1 (ICAM-1) was established as the unique hematopoietic fibrinogen receptor involved in the fibrinogen-mediated adhesion of leukocyte subsets to vascular endothelium. This conclusion was reached by using direct binding analyses, genetically developed transfectants and an affinity chromatography purification strategy. Fibrinogen binding to general vascular cell receptors connects leukocytes and endothelial cells to mediate a particular type of cell to cell adhesion. This adhesion is needed for leukocyte transport in immune-inflammatory reactions.

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Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency

Article Abstract:

Fibrinolysis is the basic and possibly only important physiological role of plasminogen (Plg). Mice deficient in Plg and fibrinogen (Fib) were generated, revealing that removal of fibrinogen from the extracellular environment alleviates the diverse spontaneous pathologies earlier linked to Plg deficiency and corrects healing times. Mice deficient in Plg and Fib were also found to have no phenotypical differences with Fib-deficient mice.

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M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage

Article Abstract:

Streptococcus pyogenes, a major human bacterial pathogen, and causes a toxic shock syndrome characterized by excessive plasma leakage and multi-organ failure. M protein released from the surface of streptococcus pyogenes forms complexes with fibrinogen, which by binding to beta2 integrins of neutrophils, activate the cells.

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