Article Abstract:
Transcription of class II genes in yeast proceeds with the transcription factor (TF) IIIC (TFIIIC) binding to the promoter, then recruiting the TFIIIB to the TFIIIC-promoter complex. With the TFIIIB bound to the complex, RNA polymerase III (pol III) is then recruited for initiation to be activated. Recent researches showed that the RNA pol III directs multiple rounds of transcription. The stability of the TFIIIB-DNA complex that recruits the pol III into the initiation complex allows the pol III to act on the same template several times to complete several initiation cycles.
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Article Abstract:
Some introns in DNA have the ability to transfer themselves to other DNA sequences which then allow these sequences to self-initiate replication by causing parallel breaks in the DNA. The transfer of these group II introns was observed in yeast cells to be mediated by RNA through a reverse-transcription mechanism. Afterwards, one strand that forms from the break undergoes replication from cDNA that carries a copy of the intron.
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Article Abstract:
A study shows that human MSX1 inhibits activation of MyoD expression in primary fibroblast x 10T1/2 cell hybrids and finds that chromosome 4, but not 8, inhibits myoD activation in 10T1/2 cell hybrids. Forced expression of Msx1 represses myoD enhancer activity. Msx1 proteins binds to the myoD enhancer and likely represses myoD transcription directly. However, antisense MSX1 relieves repression mediated by chromosome 4.
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