FOXP3 and NFAT: Partners in tolerance

Article Abstract:

A link exists between the transcriptional mechanism that facilitate recessive and dominant tolerance. The interplay of the key transcriptional regulators FOXP3 and NFAT enable T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells that suppress autoimmune responses to self-antigens.

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HIV pathogenesis: Nef loses control

Article Abstract:

A study demonstrates that the Nef protein from nonpathogenic strains of simian immunodeficiency virus (SIV) induces the down-regulation of host T cell receptor/CD3, whereas Nef from human immunodeficiency virus (HIV-1) does not. This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus.

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FOXP3 controls regulatory T cell function through cooperation with NFAT

Article Abstract:

A study is conducted to show that the forkhead transcription factor FOXP3, a lineage specification factor in cooperation with NFAT controls regulatory T cell function (Treg). NFAT switches transcriptional partners to convert the acute T cell activation program into the suppressor program of Tregs.

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