FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain

Article Abstract:

The clustering of synaptic vesicles in cultured neurons as an assay is used to purify putative target-derived presynaptic organizing molecules from mouse brain and identified FGF22 as a major active species. The results revealed that FGF22 and its relatives are presynaptic organizing molecules in the mammalian brain and suggest new functions for this family of signaling molecules.

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After the Holy Grail: establishing a molecular basis for mammalian olfaction

Article Abstract:

The importance of the characterization of molecules of mammalian odorant receptors in understanding the way neuronal systems organize sensory structures and code complex information is discussed. The role of the odorant receptor genes in the understanding of genomic organization and gene regulation is examined.

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Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins

Article Abstract:

Studies were conducted to show that neurexins are sufficient to induce glutamate postsynaptic differentiation in contacting dendrites. These studies are relevant because the formation of synaptic connections is dependent on alignment of neurotransmitter receptors on postsynaptic dendrites.

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