FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions

Article Abstract:

Microinjection of a replication-defective retrovirus that coexpresses FGF4 with beta-galactosidase into the lateral plate mesoderm in chicken embryos helps study the role of fibroblast growth factor in the temporal and regional activation of mesoderm outgrowth. Limb bud-like outgrowth is observed from cells that express exogenous FGF in the limb-forming and flank regions. Extralimb structures result from the supernumerary limb buds that are activated in limb-forming regions.

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Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signalling pathway in determination of left-right asymmetry

Article Abstract:

A common genetic basis of the development of the left-right asymmetry among vertebrates, notably chicks and mice, is investigated by monitoring the influence of the gene products of lefty-1 on Pitx2, a homeobox gene of the bicoid type located downstream of the lefty-1 gene. The expression of Pitx2 is limited on the left lateral plate mesoderm suggesting its role on the development of laterality.

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Kruppel acts as a gap gene regulating expression of hunchback and even-skipped in the intermediate germ cricket Gryllus bimaculatus

Article Abstract:

Using Gryllus bimaculatus embryos, the role of gap gene, Kruppel, in the the segmentation process of short and intermediate germ insects, is analyzed. Kruppel codes transcriptional factors which regulate gene expressions.

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