Article Abstract:
Streptococcus gordonii cells expressing the Porphyromonas gingivalis virulence factor, fimbrillin polypeptide domains on their surface inhibit the binding of P. gingivalis to saliva-coated hydroxyapatite. The S. gordonii cells bind to saliva-coated hydroxyapatite, and induce a fimbrillin-specific immune response in rabbits. The recombinant fimbrillin-expressing S. gordonii strains provide an effective vaccine for a replacement therapy against P. gingivalis. These genetically engineered streptococci modulate the microenvironment of the oral cavity.
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Article Abstract:
An attempt is made to demonstrate that Streptococcus mutans bacteriocin production is a quorumsensing-controlled phenomenon and the role of interactions with other oral bacteria on bacteriocin production by S. mutans is established. A gene, named for Streptococcus gordonii challisin was identified using transpson Tn916 mutagenesis, which is responsible for the inhibition of S. mutans bacteriocin production by S. gordonii Challis.
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Article Abstract:
A TaqMan real-time PCR assay developed to quantify the tetS gene pool present in retail cheese which offers a rapid, specific, sensitive, and culture-independent method for assessing antibiotic resistance genes in food samples rich in fats and proteins is presented.
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