Article Abstract:
Eight basic fibroblast growth factor (bGFG) transcripts were expressed during late embryonic development and in certain organs of adult chicken. An examination of bGFG antisense cDNAs revealed that they were structurally homologous to Xenophus laevis antisense transcripts. In addition, the levels of antisense and sense transcripts expressed in chicken organs were found to be inversely proportional, suggesting a regulatory role for antisense transcripts. Alternatively spliced bGFG mRNAs were also isolated. A bGFG isoform with a unique amino-terminal domain was produced when exon 1 of the open reading frame was alternatively spliced.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
The fibroblast growth factors (FGFs), FGF-2 and FGF-4, ensure the expression of Msx-1, Hoxd-13 and Bmp-2 in the posterior limb bud mesenchyme of chicken embryos. Expression of these genes are sensitive to the local signal from the apical ectodermal ridge. In the anterior cells of early bud stages, the expression of Msx-1 is based on the signals from the anterior apical ectodermal ridge. The expression of Hoxd-11 in the posterior mesenchyme is independent of the apical ectodermal ridge or FGF.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Molecular evidence shows that bone morphogenetic protein-4 (BMP-4) is essential in regulating mesodermal gene expression induced by the fibroblast growth factor (FGF)/mitogen-activated protein kinase kinase pathway in Xenopus embryo. In the absence of BMP-4, expression of the mesodermal genes containing the FGF and BMP receptors in the dorsal and ventral regions of the embryo are not maintained. Furthermore, coexpression of FGF and BMP receptors is also eliminated.
User Contributions:
Comment about this article or add new information about this topic: