Expression of a cell adhesion molecule, Neuropilin, in the developing chick nervous system

Article Abstract:

Neuropilin is a molecule active in forming synapses in some regions of the nervous system of Xenopus. To see if it exists in other species and what functions it may have, the chick embryo was studied. The amino acid sequence of the cDNA of the chick homologue of neuropilin has 75% similarity with that of Xenopus. In both animals neuropilin is localized in the fibres of the neuronal pathways and its expression is neuron-specific during neuronal development. Fibroblasts expressing neuropilin acquire cell adhesiveness by the heterophilic interactions between neuropilin and protease sensitive molecules on the fibroblasts. However its expression in the visual systems in chick and Xenopus is different.

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Activin enhances chondrogenesis of limb bud cells: stimulation of precartilaginous mesenchymal condensations and expression of NCAM

Article Abstract:

The involvement of activin in chondrogenesis was examined, as well as the effect of activin on the formation of precartilaginous condensation and the expression of neural cell adhesion molecule (NCAM). Limb bud micromass cultures were used to evaluate the ability of activin to modulate chondrogenesis. The results show that activin increases the size of precartilaginous condensations and enhances chondrogenesis of limb bud cells in culture. In addition, it increases the expression of NCAM in precartilaginous condensations.

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A functional role for the middle extracellular region of the neural cell adhesion molecule (NCAM) in axonal fasciculation and orientation

Article Abstract:

Results of an experiment using a new monoclonal antibody (m Ab HR1) revealed that the middle extracellular region of the neural cell adhesion molecule (NCAM) has an important role in the functioning of the molecule. Introduction of m Ab HR1 to intact organ-cultured eyes resulted in distorted orientation of the axonal outgrowth and fasciculation in the middle and central retina. These results indicate that the important role of the middle extracellular region of the (NCAM) in nervous systemm development.

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