Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells

Article Abstract:

The mouse t-complex resides in the proximal end of chromosome 17 and codes for genes of the major histocompatibility complex. This complex also contains the H-2K region, a segment which is actively transcribed in germ cells and early embryos. Restriction fragment length polymorphism analyses were conducted on the H-2K and flanking regions and on a homologous, duplicated region in a panel of t-haplotypes and inbred strains. The results showed that the DNA flanking the actively transcribed H2-K region is highly polymorphic, while the duplicated region is not.

author: Artzt, Karen, Young Il Yeom, Abe, Kuniya
Genetic transcription, Transcription (Genetics), Major histocompatibility complex

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Components of genetic variation in a natural population of Drosophila mercatorum

Article Abstract:

The levels of genetic variation for the three major molecular components of abnormal abdomen (aa) in Drosophila mercatorum were measured. Selective underreplication, R1 inserts and Y chromosomes with and without D bands components were noted to be highly polymorphic in D. mercatorum natural populations. The two X-linked components displayed a large number of variations in the natural population of D. mercatorum and were randomly associated. These two components were also found to form a supergene comples that regulated the aa expression in females.

author: Hollocher, Hope, Templeton, Alan R., DeSalle, Rob, Johnston, J. Spencer
Analysis, Chromosomes, Chromosome abnormalities

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Female phenotypic expression on natural genetic backgrounds and in natural environments

Article Abstract:

Wild types of Drosophila mercatorium were studied to determine if abnormal abdomen was expressed under natural conditions. Statistical analysis was used to analyze life-history data used as a measure of gene expression. Variations in fecundity were observed to differ depending on the time of sampling. Differences in fecundity disappeared after 1.5 weeks and survivorship was higher in males, although no differences were noted between males of the two stocks. Significant differences were noted in the emergence time of males and females.

author: Hollocher, Hope, Templeton, Alan R., Johnston, J. Spencer
Phenotype, Phenotypes, Molecular genetics

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subjects list: Research, Genetic aspects, Mutation (Biology), Mutation, Genetic polymorphisms, Drosophila
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