Evidence for the interplay between trehalose metabolism and Hsp104 in yeast

Article Abstract:

The consequences of the heat shock protein Hsp104 on trehalose metabolism of Saccharomyces cerevisiae were investigated through the construction of mutants carrying a disruption of the HSP104 gene. Measurement of the enzymatic activities related to trehalose metabolism indicated that the activities of trehalose-synthesizing and -hydrolyzing enzymes are low in the HSP104 disruption mutant during heat shock. Findings suggest that Hsp104 helps in the simultaneous increase in both accumulation and degradation of trehalose during heat shock.

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Physiological properties of Saccharomyces cerevisiae from which hexokinase II has been deleted

Article Abstract:

A strain of Saccharomyces cerevisiae that lacks hexokinase II shifts into a state where biomass is accumulated because glucose repression is decreased. Glucose represses many genes, including genes involved in respiration and other mitochondrial processes.

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Evidence for contribution of neutral trehalase in barotolerance of Saccharomyces cerevisiae

Article Abstract:

Neutral trehalase helps Saccharomyces cerevisiae tolerate high pressure and is especially useful when recovering from high pressure. This enzyme breaks down trehalose, which also contributes to barotolerance and thermotolerance.

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