Article Abstract:
A potential hereditary prostate cancer (PC) susceptibility locus has been shown to be on chromosome 1p36. Data from a genomic screen in 70 families with high risk for PC was combined with data from candidate-region mapping in the families and another 71 families. A significant fraction of the families with a high risk for PC and a family member with brain cancer (BC) have linkage at the 1p36 region. Cases of primary brain cancer often are seen in higher number in some families with high PC risk. Loss of heterozygosity at 1p36 is often seen in BC.
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Article Abstract:
Genetic mapping for type 1 diabetes (T1D) was performed using single-nucleotide polymorphism (SNP) markers in the 4.4-Mb human major histocompatibility complex (MHC) locus in a survey of Swedish T1D cases and controls. A peak of association within the inositol 1,4,5-triphosphate receptor 3 gene (ITPR3) is identified in the region centromeric to the MHC, and the estimated population-attributable risk suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden.
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Article Abstract:
Research attempting to link a chromosome locus to prostate cancer is inconclusive. In parametric and nonparametric testing of 152 families prone to prostate cancer, positive links were not found, even when subjects were stratified into subsets based on mean diagnosis age. A small degree of linkage was discovered among families with a minimum of five affected men.
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