Events in the onset of neural crest cell migration are separable and inducible by protein kinase inhibitors

Article Abstract:

Neural cell migration is an important part of morphogenesis. Neural tubes taken from quail embryos before epitheliomesenchymal transformation (EMT) and the migration of neural crest (NC) cells when transplanted on fibronectin surfaces undergo normal NC morphogenesis but later take longer than the cells in vivo. Protein kinase inhibitors induce immediate EMT in both the dorsal and ventral cells but the dorsal cells are more sensitive to the inhibitors. The induction of EMT by the inhibitors is probably by changes in the phosphorylation of proteins and does not involve any changes in gene expression.

author: Newgreen, D.F., Minichiello, J.
Research, Physiological aspects, Enzyme inhibitors

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Pluripotent neural crest cells in the developing skin of the quail embryo

Article Abstract:

Researchers used in vitro studies to analyze the developmental potential of mesenchymal cells obtained from explants of trunk epidermal ectoderm of the quail embryo. A significant fraction of the neural crest cells coming early in the ectoderm are pluripotent cells that can lead to the development of pigment cells, sympathoadrenal cells, primary sensory neuron precursors and probably other cells still not discussed.

author: Richardson, Michael K., Sieber-Blum, Maya
Genetic aspects

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Restoration of normal Hox code and branchial arch morphogenesis after extensive deletion of hindbrain neural crest

Article Abstract:

The head of chick embryos develops normally even when the rhombencephalic neural crest is surgically removed. This area was considered necessary for proper development of the branchial arches, but the neural crest has the ability to regenerate. All the embryos developed branchial arches, which expressed the Hox-A3 gene just as in normal embryos.

author: Krumlauf, Robb, Thorogood, Peter, Ferretti, Patrizia, Hunt, Paul
Analysis, Morphology (Biology), Morphology

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subjects list: Neural crest
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