Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast

Article Abstract:

The yeast kinetochore protein Mtw1p is required for orientation of sister kinetochores. The kinetochores separate in the very early spindle whereas the arms remain associated.

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Spindle orientation and asymmetric cell fate

Article Abstract:

The orientation of the mitotic spindle might be used to produce either an asymmetric or symmetric outcome during cell division. Interestingly the decision of the cell to divide asymmetrically depends on the plane of cell division. The asymmetric division are believed to result from an inherent intrinsic polarity of the progenitor, which demonstrated by segregation, upon division, of Notch protein to the future neuronal cell. Generation of diversity in a progeny relies on asymmetric division because asymmetric division creates daughter cells that have different fates or identities.

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Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation

Article Abstract:

Proper metaphase spindle length is set by centromere proteins Mis6 and Mis12, fission yeast sister centromere connections proteins necessary for accurate chromosome segregation. These proteins are necessary for accurate spindle morphogenesis and determine metaphase spindle length. In mis 6 (ital) and mis12 (ital) mutants 35%-60% extension of metaphse spindle length occurs.

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