Epithelial branching: The power of self-loathing

Article Abstract:

Mechanisms of epithelial branching morphogenesis, important in mammalian development, are largely unknown. A novel cell culture system is used to investigate branch-spacing mechanisms in the mammary gland, and it is suggested that epithelium-epithelium inhibitory signals mediated by TGFbeta may regulate the shape of the developing tree.

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Growing and shaping the vascular tree: multiple roles for VEGF

Article Abstract:

Vascular Endothelial Growth Factor (VEGF) integrates different modes of endothelial cell behaviour, such as proliferation, migration and specialisation to orchestrate vascular morphogenesis during embryonic development and postnatal life. It is the most potent and ubiquitous vascular growth factor.

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VEGF: Once regarded as a specific angiogenic factor, now implicated in neuroprotection

Article Abstract:

Vascular endothelial growth factor (VEGF)A is a key signal in the induction of vessel growth. Genetic studies confirm that VEGF levels may promote motor neuron degeneration by limiting neural tissue perfusion and VEGF-dependent neuroprotection.

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