EphB receptors coordinate migration and proliferation in the intestinal stem cell niche

Article Abstract:

EphB receptors regulate proliferation in the intestine, in addition to directing cell migration and EphB signaling promotes cell-cycle reentry of progenitor cells and accounts for about 50% of the mitogenic activity in the adult mouse small intestine and colon. Findings establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.

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Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment

Article Abstract:

A multiscale mathematical model of cancer invasion results that shows good predictive ability and intuitive links with cancer pathology and experimentation is reported. The model simulations predict that the genetic make-up of a cancer cell might realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces.

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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells

Article Abstract:

The expression of protease-activated receptors (PARs) is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft model. It is demonstrated that matrix metalloprotease in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.

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