Article Abstract:
Research has been conducted on the Eph receptors transducing repulsive short-range signals for axon guidance via actin dynamics modulation within growth cones. The cloning and characterization of the Eph receptor-interacting protein ephexin have been carried out and the results indicate the creation of the molecular link between Eph receptors and the actin cytoskeleton providing a localized regulation of the growth cone motility.
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Article Abstract:
Research has been conducted on the regulator of chromosome condensation (RCC1), a guanine nucleotide exchange factor for the nuclear binding protein Ran. The crystal structure of the Ran.RCC1 complex has been examined in the absence of the nucleotide and the results indicate that the nucleoside binding site's phosphate binding region is perturbed marginally due to the presence of the polyvalent anion in the P loop.
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Article Abstract:
Previous studies have established that the serine/threonine kinase Akt has the capacity to inactivate the apoptotic process. Aside from this, a recent study found that Akt is also involved with the regulation of FKHRL1 which is a member of the Forkhead family of transcription factors. Serine/threonine kinase Akt is observed to phosphorylate FKHRL1 to bind it with 14-3-3 proteins, thus, keep it within the cytoplasm.
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