Enhanced HIV-1 replication in V-beta-12 T cells due to human cytomegalovirus in monocytes: evidence for a putative herpesvirus superantigen

Article Abstract:

Human cytomegalovirus (CMV) produces V-beta-12-selective HIV-1 replication similar to the way known superantigens (SAGs) do, based on the direct interaction of T cells with CMV-infected monocytes. The monocyte-derived SAG directs HIV-1 replication to a particular V-beta subset probably initiating a viral reservoir. These findings validate previous studies on the role of MMTV SAG. The implications of the herpesvirus SAG for host-pathogen relationship in humans are discussed.

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Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts agrobacterium-mediated transformation

Article Abstract:

Study is conducted to show that flagellin and EF-Tu are shown to activate a common set of signaling events and defense responses but without clear synergistic effects. Results demonstrate that EFR is the EF-Tu receptor and that plant defense responses induced by PAMPs such as EF-Tu reduce transformation by agrobacterium.

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Factor XIIIA transglutaminase crosslinks AT(sub 1) receptor dimers of monocytes at the onset of atherosclerosis

Article Abstract:

The intracellular factor XIIIA transglutaminase crosslinks agonist-induced AT1 receptor homodimers via glutamine in the carboxyl-terminal tail of the AT1 receptor is reported. The crosslinked dimers displayed enhanced signaling and desensitization in vitro and in vivo.

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