Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster

Article Abstract:

Research has been conducted on the biosynthetic gene cluster of mersacidin. The complete sequence of the type B lantibiotic gene cluster is described.

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The lantibiotic mersacidin is an autoinducing peptide

Article Abstract:

A SigH knockout is constructed to investigate the influence of the alternative sigma factor H on mersacidin biosynthesis. The knockout mutant is asporogenous and a comparison to the wild-type strain indicated no significant differences concerning mersacidin production and immunity.

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Engineering of a novel thioether bridge and role of modified residues in the lantibiotic Pep5

Article Abstract:

The insertion of a new methyllanthionine and a didehydroalanine into the flexible portion of the peptide Pep5 decreases the peptide's antimicrobial activity. The Pep5, produced by Staphylococcus epidermis 5, contains the thioether amino acids, lanthionine and methyllanthionine, in three ring structures. Peptides without the ring structures are susceptible to proteolysis, indicating that the rings are necessary for proteolytic stability. The introduction of a thioether in Pep5 increases proteolytic stability, but decreases antimicrobial activity.

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