Endocytosis conducts the cell signaling orchestra

Article Abstract:

Eukaryotic cells use endocytosis to regulate nutrient internalization, signal transduction, and the composition of the plasma membrane. However, a more complex picture is emerging in which endocytic pathways integrate diverse signals, thereby contributing to a higher level of cellular an organismal organization and thus entocytosis and cell signaling are inter-twined in many biological processes, such as cell motility and cell fate determination.

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TTP specifically regulates the internalization of the transferrin receptor

Article Abstract:

Plasma membrane (PM) receptors are assembled from a basic structure of clathrin and clathrin adaptors. The modality of internalization of these plasma membranes is the responsibility of clathrin- coated pits (CCP) and TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor.

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Nobel celebrates the neurosciences: modulatory signaling in the brain

Article Abstract:

This essay describes contributions of three Nobel laureates in neuroscience whose discoveries have been instrumental for the current understanding of information processing within the brain. Works of Arvid Carlsson, Paul Greengard, and Eric Kandel are discussed.

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